The antonyms for the phrase "sets ease" would be any adjectives that describe a state of tension or discomfort. Some examples might include "unsettles," "irks," "bothers," "aggravates," "exasperates," or "displeases." When something sets ease, it creates a feeling of relaxation or relief, but antonyms would be any words that describe the opposite of that feeling. For instance, if a situation "unsettles" someone, it means that it is causing them to feel anxious or uneasy. Similarly, if something "irks" someone, it means it is irritating or frustrating them. Therefore, the antonyms of "sets ease" are any words that create a sense of discomfort or unease.