"Run to seed" is a phrase used to describe something that has become overgrown and unproductive. There are several synonyms for this phrase, including "go to seed," "pass its prime," "become dilapidated," "deteriorate," "degenerate," and "fall into disrepair." Additionally, this phrase can also be used to describe a person or organization that has lost its vitality or become weak due to neglect or mismanagement. Some synonyms for this meaning include "decline," "degenerate," "degenerate," "lose its edge," "fade away," and "lose momentum." Regardless of the context, "run to seed" is a phrase that conveys a sense of something that has lost its vigor and vitality and is no longer at its best.